Social structures are rapidly evolving because of emerging infectious diseases and other factors. An unprecedented crisis such as the current coronavirus pandemic requires us to implement, review, and update countermeasures quickly. Various innovations are being applied to medicine at a growing speed, contributing to people's quality of life. Innovation creation is one of the hallmarks of Osaka University. Innovation is created in a melting pot of the daily grind of laboratory work, constructive criticism, and support. Innovations often originate from new links formed between otherwise unrelated pieces of information. It is therefore important to attend brainstorming sessions that encourage members to share their ideas and information or have meetups designed to vitalize their participants, if they want to be creative. When research output is applied to practical settings, new challenges will emerge. A research and development ecosystem, in which new challenges arising from breakthroughs are brought back to the laboratory bench for further innovation, should provide an ideal platform for pursuing biomedical research. Our transdisciplinary program with a focus on industry-academia-government partnership will foster, in cooperation with private-sector partners, real innovators who can produce and practically apply excellent research output.