Theoretical analyses and experimental validation of effects caused by fluorinated substituent modification of DNA (Scientific Reports, 2020, in press)
In collaboration with Osaka University Graduate School of Medicine, Department of Gastroenterology (Profs Yuichiro Doki and Masaki Mori) and Graduate School of Pharmaceutical Sciences (Prof Obika), as well as Taiho Pharmaceutical Co., Ltd, Koseki et al. performed the structural based studies of nucleotide medicine. Given that halogen-modified nucleic acid molecules, such as trifluorothymidine (FTD) and 5-fluorouracil, are widely used in medical science and clinical site, our study focused on the reason why a large differences between FTD and 5-fluorouracil occurs. The results showed the important structural changes caused by trifluoromethyl group, for the anti-tumor effect of FTD.