Mitochondrial pyruvate carrier 1 expression controls cancer EMT and radioresistance (Cancer Sci, 2019)
In the collaboration with the Department of Radiation Oncology, Osaka University (Prof. Kazuhiko Ogawa), Takaoka, et al. investigated the mitochondrial pyruvate carriers (MPCs), key molecules in glycolysis and oxidative phosphorylation, and showed that they played critical roles in cancer metastasis. The phenomenon of epithelial-mesenchymal transition (EMT) was evaluated in the MPC-modified cells. The present study demonstrate that the MPCs are involved in the malignant behavior of epithelial cancer as therapeutic targets.