• Reproducibility of CRISPR-Cas9 Methods for generation of conditional mouse alleles: a multi-center evaluation (Genome Biology, 2019, in press)

    In collaboration with the international consortium, the efficiency and conditions were studied and elucidated for further improvement of genetic engineering technology in animal model.

  • Computational analyses for cancer biology based on exhaustive experimental backgrounds (Cancer Drug Resistance, BOOK section, 2019)

    In the view of recent advance of the field of cancer science, Koseki et al. updated the interdisciplinary knowledge and information regarding the cancer metabolism, which may be involved in causing resistance to chemotherapy for further development of precision medicine.

  • Application of C. elegans cancer screening test for the detection of pancreatic tumor in genetically engineered mice (Oncotarget, 2019).

    In collaboration with Osaka University (Prof Yuichiro Doki), Ueda et al. studied the mechanism of usefulness of Caenorhabditis elegans in the detection of cancer by urine. The genetically-engineered mice were used in the present study, which will facilitate further studies on mechanism of cancer detection by liquid biopsy in human.

  • A gemcitabine prodrug for selective treatment of pancreatic ductal adenocarcinoma (ChemMedChem, 2019, in press)

    In the collaboration with the Graduate School of Pharmaceutical Sciences, Osaka University (Prof. Satoshi Obika), Matsushita, et al. developed a gemcitabine prodrug. Given that the major concern in the use of anticancer chemotherapeutic drugs is host toxicity, this study will contribute to improve the treatment of pancreatic ductal adenocarcinoma.

  • Significant epitranscriptomes in heterogeneous cancer (Cancer Sci, 2019, in press)

    The significance of cancer RNA modification is updated and discussed and the implication is emerged in In this review article, by referring previous reports. The recent progress of epitranscriptomes (ETR) detection methods, and biological findings regarding the significance of ETR is emerged in cancer precision medicine.

  • Direct analysis of incorporation of an anticancer drug into DNA at single-molecule resolution (Scientific Reports, 2019).

    Ohshiro et al. published the novel methods and technology to study sequencing of DNA, in which trifluridine (FTD) is incorporated, at single-molecule resolution.

  • Mitochondrial pyruvate carrier 1 expression controls cancer EMT and radioresistance (Cancer Sci, 2019) 
    In the collaboration with the Department of Radiation Oncology, Osaka University (Prof. Kazuhiko Ogawa), Takaoka, et al. investigated the mitochondrial pyruvate carriers (MPCs), key molecules in glycolysis and oxidative phosphorylation, and showed that they played critical roles in cancer metastasis. The phenomenon of epithelial-mesenchymal transition (EMT) was evaluated in the MPC-modified cells. The present study demonstrate that the MPCs are involved in the malignant behavior of epithelial cancer as therapeutic targets.
  • Disruption of endolysosomal pathway efficiently eliminates colorectal cancer stem cells (Cancer Research, 2019).
    Takeda and Haraguchi published the novel discovery of colorectal cancer stem cells, as a collaboration.
  • Semaphorin signaling via MICAL3 induces symmetric cell division to expand breast cancer stem-like cells (PNAS, 2019).

    Tomonaga and Gotoh at Kanazawa University published the novel discovery of Semaphorin signaling in the study of breast cancer stem cells, as a collaboration.

  • AI for medical use (Oncotarget, 2019)
    Konno and Ishii have updated the AI issues for medical use. The recent progress and reports indicate the potential of the medical diagnosis and treatment using AI, which will be recognized in the near future.