Research Group and Staff

The focus of our lab (iLAB) includes cancer stem cells. We are developing state-of-the-art techniques that study how these cells regulate cancer development and researching new drugs that can inhibit their effects. Our research covers the basic to clinical, but we seek to build new strategic approaches that take advantage of the academic environment. One major goal is to create an accurate human cancer model. This work involves rigorous study of a number of cancer topics, including the cancer metabolism, cancer stem cells, transomics, and new biomarkers and drugs. Of special interest is TAS 102, an anticancer drug being used in ongoing clinical trials, and its effect on cancer stem cells, but we extend the research to other broadly related reagents. This drug is classified as a nucleic acid drug, as it targets specific genes that are thought to regulate the cancer. Other research on drugs and biomarkers involves the investigation of miRNA and lncRNA. We are also studying the cancer metabolism to understand how cancer develops and progresses and ways to counter these events. One carbon metabolism, because of its role in DNA synthesis and DNA methylation, is thought to have an important role in cancer stem cells. We are looking at drugs and biomarkers that target one-carbon metabolism by studying interactions between the nucleus and mitochondria, RNA modomics, genome modification, editing and transomics. Finally, we are attempting to bring machine learning into our studies. Overall, our research depends on strong industry-university collaborations towards the precision medicine, such as early diagnosis and innovative treatment of deleterious diseases, in near future.

Member

Hideshi Ishii

Link >石井 秀始 [Hideshi Ishii]

Professor,
Department of Cancer Profiling Discovery,
Graduate School of Medicine, Osaka University

M.D., Ph.D.

石井 秀始 [Hideshi Ishii]

Specialized Area

  • ・Clinical Oncology, Drug Discovery, Medical Data Science

Academic Background & Research History

  • Apr, 1988 Graduate from Chiba University School of Medicine
  • May, 1988 Resident,
    Chiba University Hospital
  • Apr, 1989 Resident,
    Chiba Municipal Hospital
  • Sep, 1989 Resident,
    Chiba Hospital of Kawasaki Steel Corporation
  • Sep, 1992 Resarch Resident,
    National Cancer Center, Resarch Institute
  • Apr, 1995 Resarcher,
    National Institute of Radiological Sciences
  • Apr, 1996 Resarcher,
    Thomas Jefferson University, U.S.
  • Jan, 2001 Famulus,
    Sidney Kimmel Comprehensive Cancer Center, U.S.
  • Oct, 2001 Lecturer,
    Sidney Kimmel Comprehensive Cancer Center, U.S.
  • Oct, 2002 Lecturer,
    Jichi Medical University
  • Apr, 2008 Associate Professor,
    Kyushu University
  • Apr, 2011 Professor,
    Department of Frontier Science for Cancer and Chemotherapy,
    Graduate School of Medicine, Osaka University
  • Apr, 2014 Professor,
    Department of Cancer Profiling Discovery,
    Graduate School of Medicine, Osaka University
  • Apr, 2017 Professor,
    Department of Medical Data Science Graduate School of Medicine, Osaka University
  • Jan, 2015 Guest Researcher,
    RIKEN Center for Integrative Medical Sciences

Masamitsu Konno

Link >今野 雅允 [Masamitsu Konno]

Assistant Professor,
Graduate School of Medicine, Osaka University

Ph.D.

Masamitsu Konno

Specialized Area

  • ・Stem Cell Biology, Regenerative Medicine

Academic Background & Research History

  • Mar, 2011Complete Graduate School,
    Graduate School of Medicine,
    Tokyo Medical and Dental University
    Ph.D. of Medicine.
  • Apr, 2011Postdoctoral fellow,
    National Center for Global Health and Medicine
  • Apr, 2012Specially Appointed Researcher,
    Graduate School of Medicine, Osaka University
  • Aug, 2012Assistant Professor,
    Graduate School of Medicine, Osaka University
  • Apr, 2017Associate Professor,
    Graduate School of Medicine, Osaka University

Jun Koseki

Link >小関 準 [Jun Koseki]

Assistant Professor,
Department of Cancer Profiling Discovery,
Graduate School of Medicine, Osaka University

Ph.D.

Jun Koseki

Specialized Area

  • ・Quantum Physical Chemistry (Molecular Orbital, Molecular Dynamics, etc.)
  • ・Physical Chemistry for Drug Design (in silico drug design, Protein structure prediction and analysis)
  • ・Trans-omics Analysis
  • ・Machine Learning, Statistical Analysis

Academic Background & Research History

  • Dec, 2010 Complete Graduate School,
    Integrated Graduate School of Art and Science,
    Yokohama City University
    Get a Ph.D. of Science
  • Jan, 2011 Postdoctoral fellow,
    Department of Quantum Physical Chemistry,
    Yokohama City University
  • Apr, 2011 Assistant Professor (Postdoctoral fellow),
    Quantum Physical Chemistry for Drug Design,
    Kitasato University School of Pharmacy

    Part-time Instructor,
    Chiba Institute of Technology
  • Apr, 2012 Assistant Professor,
    Quantum Physical Chemistry for Drug Design,
    Kitasato University School of Pharmacy
  • Apr, 2014 Assistant Professor,
    Department of Cancer Profiling Discovery,
    Graduate School of Medicine, Osaka University
  • (Concurrently)
  • Apr, 2011 Guest Researcher,
    Department of Quantum Physical Chemistry,
    Yokohama City University
  • Jan, 2015 Guest Researcher,
    RIKEN Center for Integrative Medical Sciences

Ayumu Asai

Postdoctoral Fellow,
Department of Cancer Profiling Discovery,
Graduate School of Medicine, Osaka University

Ph.D.

Ayumu Asai

Specialized Area

  • ・Pharmaceutics(Drug Delivery, Pharmaceutical Technology)
  • ・Bioinformatics
  • ・Chemistry for Drug Design

Academic Background & Research History

  • May, 2013 Famulus
    Faculty of Pharmacy, Meijo University
  • Mar, 2016 Complete Graduate School,
    Graduate School of Clinical Pharmacy
    Meijo University
  • a Ph.D. Degree of Pharmacy
  • Apr, 2016 Postdoctral Fellow
    Department of Cancer Profiling Discovery,
    Graduate School of Medicine, Osaka University

Koichi Kawamoto

Link > 川本 弘一 [Koichi Kawamoto]

Assistant Professor,
Graduate School of Medicine, Osaka University

M.D., Ph.D.

Koichi Kawamoto

Specialized Area

  • ・Hepatobiliary and Pancreatic Surgery, Transplantation Surgery

Education and Professional Experience:

  • Mar, 1997Graduated from Osaka University School of Medicine
  • Apr, 2002Graduate Student, Osaka University
  • Dec, 2008Postdoctral Fellow, Minnesota University
  • Oct, 2011Assistant Professor, Osaka University

Management General

Chihiro Ohtsuka

Graduate School of Medicine, Osaka University

Expert Technician

Miyuki Ozaki

Graduate School of Medicine, Osaka University


Yuko Noguchi

Graduate School of Medicine, Osaka University

Academia Consortium

Masaki Mori

Professor,
Department of Gastroenterological Surgery,
Graduate School of Medicine, Osaka University

Yuichiro Doki

Professor,
Department of Gastroenterological Surgery,
Graduate School of Medicine, Osaka University

Koshi Mimori

Professor,
Department of Surgery, Kyushu University Beppu Hospital

Hidetoshi Matsui

Associate Professor,
Center for Data Science Education and Research, Shiga University

Clinical Consortium

Taroh Satoh

Professor,
Graduate School of Medicine, Osaka University

Toshihiro Kudo

Assistant Professor,
Graduate School of Medicine, Osaka University

Daisuke Sakai

Assistant Professor,
Graduate School of Medicine, Osaka University

Graduate Students

― D4 ―

Kenta Tsunekuni

Department of Gastroenterological Surgery,
Graduate School of Medicine, Osaka University

Research Scientist, Laboratory for Oncology Medication Management and Development, TAIHO PHARMACEUTICAL CO., ITD.

Reishi Toshiyama

Department of Gastroenterological Surgery,
Graduate School of Medicine, Osaka University

西沢祐次郎(Yujiro Nishizawa)

大阪大学大学院 医学系研究科 消化器外科

Kosuke Taketo

Department of Radiation Oncology,
Graduate School of Medicine, Osaka University

― D3 ―

Yuji Takaoka

大阪大学大学院 医学系研究科  放射線治療学講座

Matsushita Katsunori

大阪大学大学院 医学系研究科 消化器外科

― D2 ―

Kiminori Yanagisawa

大阪大学大学院 医学系研究科 消化器外科

Yuji Ueda

大阪大学大学院 医学系研究科 消化器外科

Masayasu Toratani

大阪大学大学院 医学系研究科  放射線治療学講座

Graduates

Katsuya Ohta

Yoshihiro Kano

Shimpei Nishikawa

Atsushi Hamabe

Shinichiro Hasegawa

Hisataka Ogawa

Takahito Fukusumi

Kazuhiko Hayashi

Keisuke Tamari

Masaaki Miyo

Kozo Noguchi

Kei Asukai

Tomofumi Ohashi

Tsuyoshi Hata

Toshinori Sueda

白 成栽

Hugh Colvin